
Structure and Replication of DNA
(deoxyribonucleic acid)
A). History
1). Watson & Crick proposed double helix structure in 1953.
2). information gathered X-ray diffraction studies from Rosalind Franklin.
B). The Double Helix
1). DNA is made:
2). There are only 4 DNA nucleotides.
3). bond only with a specific complimentary nucleotide
thus:
CYTOSINE-GUANINE
GUANINE-CYTOSINE
ADENINE-THYMINE
THYMINE-ADENINE
ALWAYS
4) form double helix
C). Replication of DNA
1). The chromatin DNA helices unwinds.
2). DNA molecule separates
3). template for creating a new strand.
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. nucleotides line up next to old ones (complementary base pairing)4)
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5). DNA polymerase.
6). 2 new strands of DNA
D). Protein Synthesis Summary
E). RNA ribonucleic acid
complementary pairing:
Thymine has been replaced with URACIL
ADENINE : URACIL
URACIL : ADENINE
CYTOSINE : GUANINE
GUANINE : CYTOSINE
ALWAYS
3). Types of RNA
i). Ribosomal RNA (rRNA)
ii). Messenger RNA (mRNA)
iii). Transfer RNA (tRNA)
F).Protein Synthesis
1). Definitions
gene:
triplet: 3 base codes of DNA
codon: 3 base codes of mRNA
anticodon: 3 base pairs of tRNA
intron
exon
2). Transcription: the creation of mRNA
i). The helix is unwound
ii). The complimentary RNA bases
THYMINE : ADENINE
ADENINE: URACIL
GUANINE : CYTOSINE
CYTOSINE : GUANINE
3). The mRNA travels to the cytoplasm to a ribosome
4). Translation
i). mRNA binds to the ribosome
ii). tRNA that holds a specific amino acid binds the ribosome and a polypeptide chain is released.
iii). Complementary base pairs (anticodons) in the tRNA bind to the mRNA (codons).
URACIL : ADENINE
ADENINE: URACIL
GUANINE : CYTOSINE
CYTOSINE : GUANINE
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Summary
DNA ß RNA (tRNA, mRNA, rRNA) ß Peptide Chains ß Proteins ß Enzymes that allow all of the body’s chemistry to occur ß + Hormones that signal activity Structural Proteins which support the body
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