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DNA

 

Structure and Replication of DNA

(deoxyribonucleic acid)

A). History

    1). Watson & Crick  proposed double helix structure in 1953.

    2). information gathered  X-ray diffraction studies from Rosalind Franklin.

 

B). The Double Helix

         1).  DNA is made:    

 2). There are only 4 DNA nucleotides.

        3).  bond only with a specific complimentary nucleotide

    thus:

CYTOSINE-GUANINE

GUANINE-CYTOSINE

ADENINE-THYMINE

THYMINE-ADENINE

ALWAYS

       4) form double helix

 

C). Replication of DNA

    1). The chromatin DNA helices unwinds.

    2).  DNA molecule separates 

    3).  template for creating a new strand.

DNA DNA

4). nucleotides line up next to old ones (complementary base pairing)

DNA

        5). DNA polymerase.

        6). 2 new strands of DNA

 

D). Protein Synthesis Summary

 

 

E). RNA ribonucleic acid

             complementary pairing:

Thymine has been replaced with URACIL

ADENINE : URACIL

URACIL : ADENINE

CYTOSINE : GUANINE

GUANINE : CYTOSINE

ALWAYS

3). Types of RNA

i). Ribosomal RNA (rRNA)

                   

 ii). Messenger RNA (mRNA)

            

iii). Transfer RNA (tRNA)

F).Protein Synthesis

1). Definitions

gene:

triplet: 3 base codes of DNA

codon: 3 base codes of mRNA 

anticodon: 3 base pairs of tRNA

intron

exon

        2). Transcription: the creation of mRNA

i). The helix is unwound

ii). The complimentary RNA bases

THYMINE : ADENINE

ADENINE: URACIL

GUANINE : CYTOSINE

CYTOSINE : GUANINE

3). The mRNA travels to the cytoplasm to a ribosome

4). Translation

i).  mRNA binds to the ribosome

ii). tRNA that holds a specific amino acid binds the ribosome and a polypeptide chain is released.

iii). Complementary base pairs (anticodons) in the tRNA bind to the mRNA (codons).

 

URACIL : ADENINE

ADENINE: URACIL

GUANINE : CYTOSINE

CYTOSINE : GUANINE

 

Summary

 

DNA

ß

RNA

(tRNA, mRNA, rRNA)

ß

Peptide Chains

ß

Proteins

ß

Enzymes

that allow all of the body’s chemistry to occur

ß

+ Hormones that signal activity

Structural Proteins which support the body